Interpersonal Engagement Mediates the Relation between Maternal Affect and Externalising Behaviour in Young Children with Type 1 Diabetes

Mother-child interactions around a shared activity have been shown to play a key role in the development of young children's capacity to interact cooperatively with others. This evidence is particularly germane to type 1 diabetes (T1D) management in younger children where cooperation with parental treatment efforts is crucial for treatment success and where maternal distress and child behavioural problems are risk factors for treatment management, biomedical and psychological outcomes. In 49 4-to-8 year old children with T1D, we investigated whether the association between maternal affect and child problematic behaviour is mediated by mother-child interactions in the context of a T1D-relevant collaborative problem-solving activity. Mothers completed standardised measures of maternal and child psychological adjustment and interacted with their children in the problem-solving activity, analysed for quality of interpersonal engagement based on evaluations of maternal (sensitivity and cognitive stimulation) and dyadic (joint attention and warmth) behaviours. Mediation analyses confirmed the hypothesis that interpersonal engagement mediates the relation between maternal affective state and child behavioural problems. Specifically, more negative maternal affect is associated with lower levels of interpersonal engagement; these less engaged interactions in turn are associated with more behavioural problems in children. These findings are consistent with research involving typically developing children. The implications of our findings are twofold. First, in the context of psychological adjustment to T1D, maternal affect and mother-child interactions are 2 potential targets for interventions which promote cooperative interactions. Second, understanding and caring for children at biological risk requires attention to developmental psychology theory and method; in particular, research addressing parent-child cooperation carries both conceptual and clinical relevance.div_PaS1. Maccoby E (1992) The role of parents in the socialization of children: An historical overview. Dev Psychol 28: 1006-1017. 2. Devendra D, Liu E, Eisenbarth GS (2004) Type 1 diabetes: recent developments. Br Med J 328: 750-754. 3. Chisholm V, Atkinson L, Donaldson C, Noyes K, Payne A, et al. (2007) Predictors of treatment adherence in young children with type 1 diabetes. J Adv Nurs 57: 482-493. 4. Hilliard ME, Monaghan M, Cogen FR, Streisand R (2011) Parent stress and child behaviour among young children with type 1 diabetes. 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A deterministic algorithm for experimental design applied to tomographic and microseismic monitoring surveys

SUMMARY Most general experimental design algorithms are either: (i) stochastic and hence give different designs each time they are run with finite computing power, or (ii) deterministic but converge to results that depend on an initial or reference design, taking little or no account of the range of all other possible designs. In this paper we introduce an approximation to standard measures of experimental design quality that enables a new algorithm to be used. The algorithm is simple, deterministic and the resulting experimental design is influenced by the full range of possible designs, thus addressing problems (i) and (ii) above. Although the designs produced are not guaranteed to be globally optimal, they significantly increase the magnitude of small eigenvalues in the model–data relationship (without requiring that these eigenvalues be calculated). This reduces the model uncertainties expected post-experiment. We illustrate the method on simple tomographic and microseismic location examples with varying degrees of seismic attenuation

Maternal communication style, problem-solving and dietary adherence in young children with type 1 diabetes

The incidence of type 1 diabetes (T1D) in young children is increasing markedly however young children have been overlooked in paediatric adherence research despite the unique challenges their care presents. We investigated the relation between maternal communication style and adherence to the dietary regimen in 40 children with T1D, aged 2-8 years, and their mothers. Mothers completed measures of children's sugar consumption, parent-child communication quality, and child psychological functioning. Mothers and children engaged in a videotaped problem-solving task related to the dietary regimen, with maternal utterances analysed for behavioural control style (e.g., commands versus suggestions) and cognitive complexity (e.g., provision of labels versus questions). Maternal communications which engaged children, behaviourally and cognitively, in the task were associated with better adherence, medical, communication quality, and child adjustment outcomes. We conclude that adherence and health (medical and psychological) are optimized when young children are given opportunities to participate in their care.casl16pub1774pub

Trajectories of distress from pregnancy to 15-months post-partum during the COVID-19 pandemic

BackgroundThe COVID-19 pandemic has particularly burdened pregnant and postpartum women. It remains unclear how distress levels of pregnant and postpartum people have changed (or persisted) as the pandemic continues on and which factors may contribute to these trajectories of distress.MethodsThis longitudinal study included 304 pregnant people, who were followed during pregnancy, 6-weeks, 6-months and 15-months postpartum. At each time point, a latent “distress” factor was estimated using self-reported depressive symptoms, anxiety symptoms, and stress. Reported negative impact of COVID-19 and social support were assessed during pregnancy as risk and protective factors related to distress. Second-order latent growth curve modeling with a piecewise growth function was used to estimate initial levels and changes in distress over time.ResultsMean distress was relatively stable from the pregnancy to 6-weeks postpartum and then declined from 6-weeks to 15-months postpartum. Higher education, greater social support, and lower negative impact of COVID-19 were associated with a lower distress during pregnancy. Unexpectedly, negative impact of COVID-19 was associated with a faster decrease in distress and more social support was associated with a greater increase in distress from pregnancy to 6-weeks postpartum. However, these effects became non-significant after controlling for distress during pregnancy.ConclusionFindings indicate high but declining levels of distress from pregnancy to the postpartum period. Changes in distress are related to social support and the negative impact of the pandemic in pregnancy. Findings highlight the continued impact of COVID-19 on perinatal mental health and the need for support to limit the burden of this pandemic on pregnant people and families

Hubungan Empati Petani Dan Keterampilan Sebagai Fasilitator Di Pusat Pelatihan Pertanian Dan Pedesaan Swadaya Jawa Barat

Tujuan penelitian adalah menganalisis hubungan empati petani dan keterampilan sebagai fasilitator pembelajaran bagi para petani di Pusat Pelatihan Pertanian Swadaya (P4S). Jenis penelitian adalah survei dengan melibatkan 140 orang petani fasilitator P4S di 17 kabupaten, Provinsi Jawa Barat sebagai responden. Sebanyak 86,43% responden memiliki empati dalam kategori sedang dan 13,57% berada dalam kategori tinggi. Sebanyak 54,29% responden memiliki keterampilan memfasilitasi berada dalam kategori tinggi dan 45,71% dalam kategori sedang. Analisis korelasional menunjukkan bahwa terdapat hubungan positif yang signifikan antara empati dan keterampilan memfasilitasi (p<0,05) dengan derajat hubungan yang lemah (r=0,02)

Generalized Wong sequences and their applications to Edmonds' problems

We design two deterministic polynomial time algorithms for variants of a problem introduced by Edmonds in 1967: determine the rank of a matrix M whose entries are homogeneous linear polynomials over the integers. Given a linear subspace B of the nxn matrices over some field F, we consider the following problems: symbolic matrix rank (SMR) is the problem to determine the maximum rank among matrices in B, while symbolic determinant identity testing (SDIT) is the question to decide whether there exists a nonsingular matrix in B. The constructive versions of these problems are asking to find a matrix of maximum rank, respectively a nonsingular matrix, if there exists one. Our first algorithm solves the constructive SMR when B is spanned by unknown rank one matrices, answering an open question of Gurvits. Our second algorithm solves the constructive SDIT when B is spanned by triangularizable matrices, but the triangularization is not given explicitly. Both algorithms work over finite fields of size at least n+1 and over the rational numbers, and the first algorithm actually solves (the non-constructive) SMR independent of the field size. Our main tool to obtain these results is to generalize Wong sequences, a classical method to deal with pairs of matrices, to the case of pairs of matrix spaces

<i>In vivo</i> gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation

AbstractTherapeutics based on short interfering RNAs (siRNAs), which act by inhibiting the expression of target transcripts, represent a novel class of potent and highly specific next-generation treatments for human skin diseases. Unfortunately, the intrinsic barrier properties of the skin combined with the large size and negative charge of siRNAs make epidermal delivery of these macromolecules quite challenging. To help evaluate the in vivo activity of these therapeutics and refine delivery strategies we generated an innovative reporter mouse model that predominantly expresses firefly luciferase (luc2p) in the paw epidermis — the region of murine epidermis that most closely models the tissue architecture of human skin. Combining this animal model with state-of-the-art live animal imaging techniques, we have developed a real-time in vivo analysis work-flow that has allowed us to compare and contrast the efficacies of a wide range nucleic acid-based gene silencing reagents in the skin of live animals. While inhibition was achieved with all of the reagents tested, only the commercially available “self-delivery” modified Accell-siRNAs (Dharmacon) produced potent and sustained in vivo gene silencing. Together, these findings highlight just how informative reliable reporter mouse models can be when assessing novel therapeutics in vivo. Using this work-flow, we developed a novel clinically-relevant topical formulation that facilitates non-invasive epidermal delivery of unmodified and “self-delivery” siRNAs. Remarkably, a sustained >40% luc2p inhibition was observed after two 1-hour treatments with Accell-siRNAs in our topical formulation. Importantly, our ability to successfully deliver siRNA molecules topically brings these novel RNAi-based therapeutics one-step closer to clinical use